Targeting the CALR interactome in myeloproliferative neoplasms

Mutations in the ER chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL), and mediate constitutive JAK/STAT signaling. The mechanisms by which CALR mutations cause myeloid transformation are incompletely defined. We used m...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Pronier, Elodie, Cifani, Paolo, Merlinsky, Tiffany R., Berman, Katharine Barr, Somasundara, Amritha Varshini Hanasoge, Rampal, Raajit K., LaCava, John, Wei, Karen E., Pastore, Friederike, Maag, Jesper L.V., Park, Jane, Koche, Richard, Kentsis, Alex, Levine, Ross L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302938/
https://ncbi.nlm.nih.gov/pubmed/30429377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122703
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