New approaches for predicting T cell–mediated drug reactions: A role for inducible and potentially preventable autoimmunity

Por Michels, Aaron W., Ostrov, David A.
Publicado no J Allergy Clin Immunol (2015)

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

Por Pirmohamed, Munir, Ostrov, David A., Park, B. Kevin
Publicado no J Allergy Clin Immunol (2015)

Identification of adenine nucleotide translocase 4 inhibitors by molecular docking

Por Leung, Wai-Yee, Hamazaki, Takashi, Ostrov, David A., Terada, Naohiro
Publicado em 2013

Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis

Por Ratnayake, Wishrawana S., Apostolatos, André H., Ostrov, David A., Acevedo-Duncan, Mildred
Publicado no Int J Oncol (2017)

Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor

Por Toro, Edgardo J, Ostrov, David A, Wronski, Thomas J, Holliday, L Shannon
Publicado em 2012

Molecular Modeling Optimization of Anticoagulant Pyridine Derivatives

Por Hernandez Prada, Jose A., Madden, Sandra L., Ostrov, David A., Hernandez, Maria A.
Publicado em 2008

Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3

Por Graham, W. Vallen, Magis, Andrew T., Bailey, Kate M., Turner, Jerrold R., Ostrov, David A.
Publicado em 2011

DNA Polymerase β as a Novel Target for Chemotherapeutic Intervention of Colorectal Cancer

Por Jaiswal, Aruna S., Banerjee, Sanjeev, Aneja, Ritu, Sarkar, Fazlul H., Ostrov, David A., Narayan, Satya
Publicado em 2011

Z3, a Novel Jak2 Tyrosine Kinase Small Molecule Inhibitor that Suppresses Jak2-mediated Pathologic Cell Growth

Por Sayyah, Jacqueline, Magis, Andrew, Ostrov, David A., Allan, Robert W., Braylan, Raul C., Sayeski, Peter P.
Publicado em 2008

The Small Molecule Chloropyramine Hydrochloride (C4) Targets the Binding Site of Focal Adhesion Kinase and Vascular Endothelial Growth Factor Receptor 3 and Suppresses Breast Cance...

Por Kurenova, Elena V., Hunt, Darell L., He, Dihua, Magis, Andrew T., Ostrov, David A., Cance, William G.
Publicado em 2009

Functional Expression of Human Adenine Nucleotide Translocase 4 in Saccharomyces Cerevisiae

Por Hamazaki, Takashi, Leung, Wai-Yee, Cain, Brian D., Ostrov, David A., Thorsness, Peter E., Terada, Naohiro
Publicado em 2011

Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease

Por Ezgimen, Manolya, Lai, Huiguo, Mueller, Niklaus H., Lee, Kyungae, Cuny, Gregory, Ostrov, David A., Padmanabhan, Radhakrishnan
Publicado em 2012

Identification of Tyrosine 972 as a Novel Site of Jak2 Tyrosine Kinase Phosphorylation and its Role in Jak2 Activation

Por McDoom, Issam, Ma, Xianyue, Kirabo, Annet, Lee, Kuang-Yung, Ostrov, David A., Sayeski, Peter P.
Publicado em 2008

Development of novel Asf1-H3/H4 inhibitors

Por Miknis, Greg F., Stevens, Sarah J., Smith, Luke E., Ostrov, David A., Churchill, Mair E.A.
Publicado no Bioorg Med Chem Lett (2014)

Recognition of additional roles for immunoglobulin domains in immune function

Por Cannon, John P., Dishaw, Larry J., Haire, Robert N., Litman, Ronda T., Ostrov, David A., Litman, Gary W.
Publicado em 2009

Potent Elastase Inhibitors from Cyanobacteria: Structural Basis and Mechanisms Mediating Cytoprotective and Anti-inflammatory Effects in Bronchial Epithelial Cells

Por Salvador, Lilibeth A., Taori, Kanchan, Biggs, Jason S., Jakoncic, Jean, Ostrov, David A., Paul, Valerie J., Luesch, Hendrik
Publicado em 2013

Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir

Por Thomas, Mark, Hopkins, Chris, Duffy, Eamon, Lee, Daniel, Loulergue, Pierre, Ripamonti, Diego, Ostrov, David A., Phillips, Elizabeth
Publicado no Clin Infect Dis (2017)

Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening

Por Ostrov, David A., Hernández Prada, José A., Corsino, Patrick E., Finton, Kathryn A., Le, Nhan, Rowe, Thomas C.
Publicado em 2007

Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group

Por Magis, Andrew T., Bailey, Kate M., Kurenova, Elena V., Hernández Prada, Jose A., Cance, William G., Ostrov, David A.
Publicado em 2008

A novel inhibitor of DNA polymerase β enhances the ability of Temozolomide to impair the growth of colon cancer cells

Por Jaiswal, Aruna S., Banerjee, Sanjeev, Panda, Harekrushna, Bulkin, Charles D., Izumi, Tadahide, Sarkar, Fazlul H., Ostrov, David A., Narayan, Satya
Publicado em 2009