Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis

Atypical protein kinase Cs (aPKC) are involved in cell cycle progression, tumorigenesis, cell survival and migration in many cancers. We believe that aPKCs play an important role in cell motility of melanoma by regulating cell signaling pathways and inducing epithelial to mesenchymal transition (EMT...

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Bibliografiska uppgifter
I publikationen:Int J Oncol
Huvudupphovsmän: Ratnayake, Wishrawana S., Apostolatos, André H., Ostrov, David A., Acevedo-Duncan, Mildred
Materialtyp: Artigo
Språk:Inglês
Publicerad: D.A. Spandidos 2017
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642393/
https://ncbi.nlm.nih.gov/pubmed/29048609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2017.4131
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