Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway

PURPOSE: The options for treating lung cancers are limited, as diagnosis typically occurs during the late stages of the disease. There is a dire need to develop aPKC (atypical Protein Kinase C) inhibitors due to aPKC overexpression and contributions to lung cancer malignancies. In this study, we inv...

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Veröffentlicht in:Onco Targets Ther
Hauptverfasser: BommaReddy, Raja Reddy, Patel, Rekha, Smalley, Tracess, Acevedo-Duncan, Mildred
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047975/
https://ncbi.nlm.nih.gov/pubmed/32158232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S224866
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