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Identification of Tyrosine 972 as a Novel Site of Jak2 Tyrosine Kinase Phosphorylation and its Role in Jak2 Activation

Jak2 is a 130 kDa tyrosine kinase that is important in a number of cellular signaling pathways. Its function is intrinsically regulated by the phosphorylation of a handful of its 49 tyrosines. Here, we report that tyrosine 972 (Y972) is a novel site of Jak2 phosphorylation, and hence auto-regulation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McDoom, Issam, Ma, Xianyue, Kirabo, Annet, Lee, Kuang-Yung, Ostrov, David A., Sayeski, Peter P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636534/
https://ncbi.nlm.nih.gov/pubmed/18636744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800867d
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