Tyrosines 868, 966, and 972 in the Kinase Domain of JAK2 Are Autophosphorylated and Required for Maximal JAK2 Kinase Activity

Janus kinase 2 (JAK2) is activated by a majority of cytokine family receptors including receptors for GH, leptin, and erythropoietin. To identify novel JAK2-regulatory and/or -binding sites, we set out to identify autophosphorylation sites in the kinase domain of JAK2. Two-dimensional phosphopeptide...

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Main Authors: Argetsinger, Lawrence S., Stuckey, Jeanne A., Robertson, Scott A., Koleva, Rositsa I., Cline, Joel M., Marto, Jarrod A., Myers, Martin G., Carter-Su, Christin
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870937/
https://ncbi.nlm.nih.gov/pubmed/20304997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0355
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