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Regulation of Jak2 Function by Phosphorylation of Tyr(317) and Tyr(637) during Cytokine Signaling

Jak2, the cognate tyrosine kinase for numerous cytokine receptors, undergoes multisite phosphorylation during cytokine stimulation. To understand the role of phosphorylation in Jak2 regulation, we used mass spectrometry to identify numerous Jak2 phosphorylation sites and characterize their significa...

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Détails bibliographiques
Auteurs principaux: Robertson, Scott A., Koleva, Rositsa I., Argetsinger, Lawrence S., Carter-Su, Christin, Marto, Jarrod A., Feener, Edward P., Myers, Martin G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698725/
https://ncbi.nlm.nih.gov/pubmed/19364823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00278-09
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