Phosphorylation of Jak2 on Ser(523) Inhibits Jak2-Dependent Leptin Receptor Signaling

The leptin receptor, LRb, and other cytokine receptors are devoid of intrinsic enzymatic activity and rely upon the activity of constitutively associated Jak family tyrosine kinases to mediate intracellular signaling. In order to clarify mechanisms by which Jak2, the cognate LRb-associated Jak kinas...

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Bibliographic Details
Main Authors: Ishida-Takahashi, Ryoko, Rosario, Felicia, Gong, Yusong, Kopp, Keely, Stancheva, Zlatina, Chen, Xiaohong, Feener, Edward P., Myers, Martin G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489076/
https://ncbi.nlm.nih.gov/pubmed/16705160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01589-05
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