Insufficiency of Janus Kinase 2–Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions

OBJECTIVE: Leptin acts via its receptor (LepRb) to signal the status of body energy stores. Leptin binding to LepRb initiates signaling by activating the associated Janus kinase 2 (Jak2) tyrosine kinase, which promotes the phosphorylation of tyrosine residues on the intracellular tail of LepRb. Two...

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Detalhes bibliográficos
Main Authors: Robertson, Scott, Ishida-Takahashi, Ryoko, Tawara, Isao, Hu, Jiang, Patterson, Christa M., Jones, Justin C., Kulkarni, Rohit N., Myers, Martin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844825/
https://ncbi.nlm.nih.gov/pubmed/20068132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1556
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