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A novel inhibitor of DNA polymerase β enhances the ability of Temozolomide to impair the growth of colon cancer cells

The recent emerging concept to sensitize cancer cells to DNA-alkylating drugs is by inhibiting various proteins in the base excision repair (BER) pathway. In the present study, we used structure-based molecular docking of DNA polymerase β (Pol-β) and identified a potent small molecular weight inhibi...

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Detalhes bibliográficos
Main Authors: Jaiswal, Aruna S., Banerjee, Sanjeev, Panda, Harekrushna, Bulkin, Charles D., Izumi, Tadahide, Sarkar, Fazlul H., Ostrov, David A., Narayan, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796282/
https://ncbi.nlm.nih.gov/pubmed/19996303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0309
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