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The Small Molecule Chloropyramine Hydrochloride (C4) Targets the Binding Site of Focal Adhesion Kinase and Vascular Endothelial Growth Factor Receptor 3 and Suppresses Breast Cancer Growth in vivo

FAK is a tyrosine kinase that functions as a key orchestrator of signals leading to invasion and metastasis. Since FAK interacts directly with a number of critical proteins involved in survival signaling in tumor cells, we hypothesized that targeting a key protein-protein interface with drug-like sm...

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Detalhes bibliográficos
Main Authors: Kurenova, Elena V., Hunt, Darell L., He, Dihua, Magis, Andrew T., Ostrov, David A., Cance, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765121/
https://ncbi.nlm.nih.gov/pubmed/19610651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900159g
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