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A small molecule inhibitor 1,2,4,5-Benzenetetraamine tetrahydrochloride, targeting the Y397 site of Focal Adhesion Kinase decreases tumor growth
Focal Adhesion Kinase (FAK) is a non-receptor kinase that is overexpressed in many types of tumors. We developed a novel cancer-therapy approach, targeting the main autophosphorylation site of FAK, Y397 by computer modeling and screening of the National Cancer Institute (NCI) small molecule compound...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662449/ https://ncbi.nlm.nih.gov/pubmed/18989950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800483v |
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