The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer

Por Abed, Mona, Bitman-Lotan, Eliya, Orian, Amir
Publicado no J Dev Biol (2018)

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes

Por Hook, Sara S., Orian, Amir, Cowley, Shaun M., Eisenman, Robert N.
Publicado em 2002

Isoform-Specific SCF(Fbw7) Ubiquitination Mediates Differential Regulation of PGC-1α

Por Trausch-Azar, Julie S., Abed, Mona, Orian, Amir, Schwartz, Alan L.
Publicado no J Cell Physiol (2015)

Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain

Por Orian, Amir, Schwartz, Alan L., Israël, Alain, Whiteside, Simon, Kahana, Chaim, Ciechanover, Aaron
Publicado em 1999

Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

Por Yanku, Yifat, Bitman-Lotan, Eliya, Zohar, Yaniv, Kurant, Estee, Zilke, Norman, Eilers, Martin, Orian, Amir
Publicado no Cells (2018)

Hairy Transcriptional Repression Targets and Cofactor Recruitment in Drosophila

Por Bianchi-Frias, Daniella, Orian, Amir, Delrow, Jeffrey J, Vazquez, Julio, Rosales-Nieves, Alicia E, Parkhurst, Susan M
Publicado em 2004

The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis

Por Barry, Kevin C., Abed, Mona, Kenyagin, Dorit, Werwie, Timothy R., Boico, Olga, Orian, Amir, Parkhurst, Susan M.
Publicado em 2011

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Por Welcker, Markus, Orian, Amir, Jin, Jianping, Grim, Jonathan A., Harper, J. Wade, Eisenman, Robert N., Clurman, Bruce E.
Publicado em 2004

Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression

Por Abed, Mona, Barry, Kevin C, Kenyagin, Dorit, Koltun, Bella, Phippen, Taryn M, Delrow, Jeffrey J, Parkhurst, Susan M, Orian, Amir
Publicado em 2011

Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development

Por Singer, Ruth, Atar, Shimshi, Atias, Osnat, Oron, Efrat, Segal, Daniel, Hirsch, Joel A., Tuller, Tamir, Orian, Amir, Chamovitz, Daniel A.
Publicado em 2014

SCF(β-TrCP) ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase

Por Orian, Amir, Gonen, Hedva, Bercovich, Beatrice, Fajerman, Ifat, Eytan, Esther, Israël, Alain, Mercurio, Frank, Iwai, Kazuhiro, Schwartz, Alan L., Ciechanover, Aaron
Publicado em 2000

The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis

Por Herkert, Barbara, Dwertmann, Anne, Herold, Steffi, Abed, Mona, Naud, Jean-Francois, Finkernagel, Florian, Harms, Gregory S., Orian, Amir, Wanzel, Michael, Eilers, Martin
Publicado em 2010

The transcription factor Hey and nuclear lamins specify and maintain cell identity

Por Flint Brodsly, Naama, Bitman-Lotan, Eliya, Boico, Olga, Shafat, Adi, Monastirioti, Maria, Gessler, Manfred, Delidakis, Christos, Rincon-Arano, Hector, Orian, Amir
Publicado no eLife (2019)

A Myc–Groucho complex integrates EGF and Notch signaling to regulate neural development

Por Orian, Amir, Delrow, Jeffrey J., Rosales Nieves, Alicia E., Abed, Mona, Metzger, David, Paroush, Ze'ev, Eisenman, Robert N., Parkhurst, Susan M.
Publicado em 2007

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

Por Wang, Ming, Sang, Jing, Ren, Yanhua, Liu, Kejia, Liu, Xinyi, Zhang, Jian, Wang, Haolu, Wang, Jian, Orian, Amir, Yang, Jie, Yi, Jing
Publicado no Protein Cell (2015)

Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila

Por Cammarata-Mouchtouris, Alexandre, Nguyen, Xuan-Hung, Acker, Adrian, Bonnay, François, Goto, Akira, Orian, Amir, Fauvarque, Marie-Odile, Boutros, Michael, Reichhart, Jean-Marc, Matt, Nicolas
Publicado no PLoS Pathog (2020)

RNF4-Dependent Oncogene Activation by Protein Stabilization

Por Thomas, Jane J., Abed, Mona, Heuberger, Julian, Novak, Rostislav, Zohar, Yaniv, Beltran Lopez, Angela P., Trausch-Azar, Julie S., Ilagan, Ma. Xenia G., Benhamou, David, Dittmar, Gunnar, Kopan, Raphael, Birchmeier, Walter, Schwartz, Alan L., Orian, Amir
Publicado no Cell Rep (2016)

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

Por Orian, Amir, van Steensel, Bas, Delrow, Jeffrey, Bussemaker, Harmen J., Li, Ling, Sawado, Tomoyuki, Williams, Eleanor, Loo, Lenora W.M., Cowley, Shaun M., Yost, Cynthia, Pierce, Sarah, Edgar, Bruce A., Parkhurst, Susan M., Eisenman, Robert N.
Publicado em 2003

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

Por Prieto‐Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Braun, Fabian, Fischer, Thomas, Walz, Susanne, Schülein‐Völk, Christina, Eilers, Ursula, Ade, Carsten P, Calzado, Marco A, Orian, Amir, Maric, Hans M, Münch, Christian, Rosenfeldt, Mathias, Eilers, Martin, Diefenbacher, Markus E
Publicado no EMBO Mol Med (2020)

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(−/−) mice

Por Li, Yan, Tinoco, Roberto, Elmén, Lisa, Segota, Igor, Xian, Yibo, Fujita, Yu, Sahu, Avinash, Zarecki, Raphy, Marie, Kerrie, Feng, Yongmei, Khateb, Ali, Frederick, Dennie T., Ashkenazi, Shiri K., Kim, Hyungsoo, Perez, Eva Guijarro, Day, Chi-Ping, Segura Muñoz, Rafael S., Schmaltz, Robert, Yooseph, Shibu, Tam, Miguel A., Zhang, Tongwu, Avitan-Hersh, Emily, Tzur, Lihi, Roizman, Shoshana, Boyango, Ilanit, Bar-Sela, Gil, Orian, Amir, Kaufman, Randal J., Bosenberg, Marcus, Goding, Colin R., Baaten, Bas, Levesque, Mitchell P., Dummer, Reinhard, Brown, Kevin, Merlino, Glenn, Ruppin, Eytan, Flaherty, Keith, Ramer-Tait, Amanda, Long, Tao, Peterson, Scott N., Bradley, Linda M., Ronai, Ze’ev A.
Publicado no Nat Commun (2019)