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Isoform-Specific SCF(Fbw7) Ubiquitination Mediates Differential Regulation of PGC-1α
The E3 ubiquitin ligase and tumor suppressor SCF(Fbw7) exists as three isoforms that govern the degradation of a host of critical cell regulators, including c-Myc, cyclin E, and PGC-1α. Peroxisome proliferator activated receptor-gamma coactivator 1α (PGC-1α) is a transcriptional coactivator with bro...
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| Publicado no: | J Cell Physiol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4596538/ https://ncbi.nlm.nih.gov/pubmed/25204433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24812 |
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