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Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase
The SCF(FBW7) ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2426948/ https://ncbi.nlm.nih.gov/pubmed/18559665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200802076 |
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