Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

The SCF(FBW7) ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting...

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Detalhes bibliográficos
Main Authors: Grim, Jonathan E., Gustafson, Michael P., Hirata, Roli K., Hagar, Amanda C., Swanger, Jherek, Welcker, Markus, Hwang, Harry C., Ericsson, Johan, Russell, David W., Clurman, Bruce E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426948/
https://ncbi.nlm.nih.gov/pubmed/18559665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200802076
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