Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

The SCF(FBW7) ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting...

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Hlavní autoři: Grim, Jonathan E., Gustafson, Michael P., Hirata, Roli K., Hagar, Amanda C., Swanger, Jherek, Welcker, Markus, Hwang, Harry C., Ericsson, Johan, Russell, David W., Clurman, Bruce E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2008
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426948/
https://ncbi.nlm.nih.gov/pubmed/18559665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200802076
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