Fbw7 dimerization determines the specificity and robustness of substrate degradation

The Fbw7 tumor suppressor targets a broad network of proteins for ubiquitylation. Here we show critical functions for Fbw7 dimerization in regulating the specificity and robustness of degradation. Dimerization enables Fbw7 to target substrates through concerted binding to two suboptimal and independ...

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Detaylı Bibliyografya
Asıl Yazarlar: Welcker, Markus, Larimore, Elizabeth A., Swanger, Jherek, Bengoechea-Alonso, Maria T., Grim, Jonathan E., Ericsson, Johan, Zheng, Ning, Clurman, Bruce E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2013
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861666/
https://ncbi.nlm.nih.gov/pubmed/24298052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.229195.113
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