Fbw7 dimerization determines the specificity and robustness of substrate degradation

The Fbw7 tumor suppressor targets a broad network of proteins for ubiquitylation. Here we show critical functions for Fbw7 dimerization in regulating the specificity and robustness of degradation. Dimerization enables Fbw7 to target substrates through concerted binding to two suboptimal and independ...

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Main Authors: Welcker, Markus, Larimore, Elizabeth A., Swanger, Jherek, Bengoechea-Alonso, Maria T., Grim, Jonathan E., Ericsson, Johan, Zheng, Ning, Clurman, Bruce E.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2013
主題:
Research Communication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861666/
https://ncbi.nlm.nih.gov/pubmed/24298052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.229195.113
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