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Ras activity regulates cyclin E degradation by the Fbw7 pathway
The Skp1–Cullin1 F-box protein–Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis. Fbw7 is a human tumor suppressor that is targeted for mutation in primary cancers. However, mechanis...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1172263/ https://ncbi.nlm.nih.gov/pubmed/15980150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503677102 |
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