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Fbw7/hCDC4 dimerization regulates its substrate interactions

BACKGROUND: The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been shown to dimerize. In this study, we asked whether Fbw7 can also dimerize and ho...

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Bibliografski detalji
Glavni autori: Welcker, Markus, Clurman, Bruce E
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802738/
https://ncbi.nlm.nih.gov/pubmed/17298674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-2-7
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