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Fbw7/hCDC4 dimerization regulates its substrate interactions
BACKGROUND: The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been shown to dimerize. In this study, we asked whether Fbw7 can also dimerize and ho...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1802738/ https://ncbi.nlm.nih.gov/pubmed/17298674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-2-7 |
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