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Isoform-Specific SCF(Fbw7) Ubiquitination Mediates Differential Regulation of PGC-1α

The E3 ubiquitin ligase and tumor suppressor SCF(Fbw7) exists as three isoforms that govern the degradation of a host of critical cell regulators, including c-Myc, cyclin E, and PGC-1α. Peroxisome proliferator activated receptor-gamma coactivator 1α (PGC-1α) is a transcriptional coactivator with bro...

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Publicat a:J Cell Physiol
Autors principals: Trausch-Azar, Julie S., Abed, Mona, Orian, Amir, Schwartz, Alan L.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596538/
https://ncbi.nlm.nih.gov/pubmed/25204433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24812
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