The SCF(FBW7) ubiquitin ligase complex as a tumor suppressor in T cell leukemia

Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T cell acute lymphoblastic leukemia (T-ALL) cases. Most of these mutations truncate its C-terminal domain, a region that is important for the NOTCH1 proteasome-mediated degradation. We report that the E...

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Main Authors: Thompson, Benjamin J., Buonamici, Silvia, Sulis, Maria Luisa, Palomero, Teresa, Vilimas, Tomas, Basso, Giuseppe, Ferrando, Adolfo, Aifantis, Iannis
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2007
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118676/
https://ncbi.nlm.nih.gov/pubmed/17646408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070872
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