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The SCF(FBW7) ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T cell acute lymphoblastic leukemia (T-ALL) cases. Most of these mutations truncate its C-terminal domain, a region that is important for the NOTCH1 proteasome-mediated degradation. We report that the E...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118676/ https://ncbi.nlm.nih.gov/pubmed/17646408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070872 |
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