Regulation of leukemia-initiating cell activity by the ubiquitin ligase FBXW7

Sequencing efforts led to the identification of somatic mutations that could affect self-renewal and differentiation of cancer-initiating cells. One such recurrent mutation targets the binding pocket of the ubiquitin ligase FBXW7. Missense FBXW7 mutations are prevalent in various tumors, including T...

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Bibliografiska uppgifter
Huvudupphovsmän: King, Bryan, Trimarchi, Thomas, Reavie, Linsey, Xu, Luyao, Mullenders, Jasper, Ntziachristos, Panagiotis, Aranda-Orgilles, Beatriz, Perez-Garcia, Arianne, Shi, Junwei, Vakoc, Christopher, Sandy, Peter, Shen, Steven S., Ferrando, Adolfo, Aifantis, Iannis
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146439/
https://ncbi.nlm.nih.gov/pubmed/23791182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.041
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