Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

Ubiquitination is a posttranslational mechanism that controls diverse cellular processes. We focus here on the ubiquitin ligase Fbw7, a recently identified hematopoietic tumor suppressor that can target for degradation several important oncogenes, including Notch1, c-Myc, and cyclin E. We have gener...

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Hauptverfasser: Thompson, Benjamin J., Jankovic, Vladimir, Gao, Jie, Buonamici, Silvia, Vest, Alan, Lee, Jennifer May, Zavadil, Jiri, Nimer, Stephen D., Aifantis, Iannis
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413036/
https://ncbi.nlm.nih.gov/pubmed/18474632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080277
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