Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression

Transcriptional cofactors are essential for proper embryonic development. One such cofactor in Drosophila, Degringolade (Dgrn), encodes a RING finger/E3 ubiquitin ligase. Dgrn and its mammalian ortholog RNF4 are SUMO-targeted ubiquitin ligases (STUbLs). STUbLs bind to SUMOylated proteins via their S...

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Detalhes bibliográficos
Main Authors: Abed, Mona, Barry, Kevin C, Kenyagin, Dorit, Koltun, Bella, Phippen, Taryn M, Delrow, Jeffrey J, Parkhurst, Susan M, Orian, Amir
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094120/
https://ncbi.nlm.nih.gov/pubmed/21343912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.42
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