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The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis

Degringolade (Dgrn) encodes a Drosophila SUMO-targeted ubiquitin ligase (STUbL) protein similar to that of mammalian RNF4. Dgrn facilitates the ubiquitylation of the HES protein Hairy, which disrupts the repressive activity of Hairy by inhibiting the recruitment of its cofactor Groucho. We show that...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Barry, Kevin C., Abed, Mona, Kenyagin, Dorit, Werwie, Timothy R., Boico, Olga, Orian, Amir, Parkhurst, Susan M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Company of Biologists 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074452/
https://ncbi.nlm.nih.gov/pubmed/21486924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.058420
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