The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis

Degringolade (Dgrn) encodes a Drosophila SUMO-targeted ubiquitin ligase (STUbL) protein similar to that of mammalian RNF4. Dgrn facilitates the ubiquitylation of the HES protein Hairy, which disrupts the repressive activity of Hairy by inhibiting the recruitment of its cofactor Groucho. We show that...

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Библиографические подробности
Главные авторы: Barry, Kevin C., Abed, Mona, Kenyagin, Dorit, Werwie, Timothy R., Boico, Olga, Orian, Amir, Parkhurst, Susan M.
Формат: Artigo
Язык:Inglês
Опубликовано: Company of Biologists 2011
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074452/
https://ncbi.nlm.nih.gov/pubmed/21486924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.058420
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