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The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

SUMO-targeted ubiquitin ligases (STUbLs) mediate the ubiquitylation of SUMOylated proteins to modulate their functions. In search of direct targets for the STUbL RNF4, we have developed TULIP (targets for ubiquitin ligases identified by proteomics) to covalently trap targets for ubiquitin E3 ligases...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Kumar, Ramesh, González-Prieto, Román, Xiao, Zhenyu, Verlaan-de Vries, Matty, Vertegaal, Alfred C. O.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703878/
https://ncbi.nlm.nih.gov/pubmed/29180619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01900-x
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