Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

The HECT-type ubiquitin ligase HECT, UBA and WWE Domain Containing 1, (HUWE1) regulates key cancer-related pathways, including the Myc oncogene. It affects cell proliferation, stress and immune signaling, mitochondria homeostasis, and cell death. HUWE1 is evolutionarily conserved from Caenorhabditis...

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Udgivet i:Cells
Main Authors: Yanku, Yifat, Bitman-Lotan, Eliya, Zohar, Yaniv, Kurant, Estee, Zilke, Norman, Eilers, Martin, Orian, Amir
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210797/
https://ncbi.nlm.nih.gov/pubmed/30261639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7100151
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