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A conformational switch regulates the ubiquitin ligase HUWE1
The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is unkown how its activity is regulated. We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibited dimer. We show that HUWE1 dimerizes in solution and...
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| Publicado en: | eLife |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5308896/ https://ncbi.nlm.nih.gov/pubmed/28193319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21036 |
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