טוען...
A conformational switch regulates the ubiquitin ligase HUWE1
The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is unkown how its activity is regulated. We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibited dimer. We show that HUWE1 dimerizes in solution and...
שמור ב:
| הוצא לאור ב: | eLife |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
eLife Sciences Publications, Ltd
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5308896/ https://ncbi.nlm.nih.gov/pubmed/28193319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21036 |
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