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A conformational switch regulates the ubiquitin ligase HUWE1

The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is unkown how its activity is regulated. We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibited dimer. We show that HUWE1 dimerizes in solution and...

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Pubblicato in:eLife
Autori principali: Sander, Bodo, Xu, Wenshan, Eilers, Martin, Popov, Nikita, Lorenz, Sonja
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308896/
https://ncbi.nlm.nih.gov/pubmed/28193319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21036
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