The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer

Por O'Malley, Tiernan T., Witbold, William M., Linse, Sara, Walsh, Dominic M.
Publicado no Biochemistry (2016)

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

Por Yang, Ting, Hong, Soyon, O’Malley, Tiernan, Sperling, Reisa A., Walsh, Dominic M., Selkoe, Dennis J.
Publicado em 2013

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

Por Hong, Soyon, Ostaszewski, Beth L., Yang, Ting, O'Malley, Tiernan T., Jin, Ming, Yanagisawa, Katsuhiko, Li, Shaomin, Bartels, Tim, Selkoe, Dennis J.
Publicado em 2014

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity

Por Hu, Neng-Wei, Corbett, Grant T., Moore, Steven, Klyubin, Igor, O’Malley, Tiernan T., Walsh, Dominic M., Livesey, Frederick J., Rowan, Michael J.
Publicado no Cell Rep (2018)

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

Por Yang, Ting, O’Malley, Tiernan T, Kanmert, Daniel, Jerecic, Jasna, Zieske, Lynn R, Zetterberg, Henrik, Hyman, Bradley T, Walsh, Dominic M, Selkoe, Dennis J
Publicado no Alzheimers Res Ther (2015)

Soluble Aβ Oligomers Impair Hippocampal LTP by Disrupting Glutamatergic/GABAergic Balance

Por Lei, Ming, Xu, Huixin, Li, Zhangyuan, Wang, Zemin, O’Malley, Tiernan T., Zhang, Dainan, Walsh, Dominic M., Xu, Pingyi, Selkoe, Dennis J., Li, Shaomin
Publicado no Neurobiol Dis (2015)

IgG Conformer's Binding to Amyloidogenic Aggregates

Por Phay, Monichan, Welzel, Alfred T., Williams, Angela D., McWilliams-Koeppen, Helen P., Blinder, Veronika, O'Malley, Tiernan T., Solomon, Alan, Walsh, Dominic M., O'Nuallain, Brian
Publicado no PLoS One (2015)

The aqueous phase of Alzheimer’s disease brain contains assemblies built from ~4 and ~7 kDa Aβ species

Por Mc Donald, Jessica M., O’Malley, Tiernan T., Liu, Wen, Mably, Alexandra J., Brinkmalm, Gunnar, Portelius, Erik, Wittbold, William M., Frosch, Matthew P., Walsh, Dominic M.
Publicado no Alzheimers Dement (2015)

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

Por Hu, Neng-Wei, Nicoll, Andrew J., Zhang, Dainan, Mably, Alexandra J., O’Malley, Tiernan, Purro, Silvia A., Terry, Cassandra, Collinge, John, Walsh, Dominic M., Rowan, Michael J.
Publicado no Nat Commun (2014)

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

Por Jin, Ming, O’Nuallain, Brian, Hong, Wei, Boyd, Justin, Lagomarsino, Valentina N., O’Malley, Tiernan T., Liu, Wen, Vanderburg, Charles R., Frosch, Matthew P., Young-Pearse, Tracy, Selkoe, Dennis J., Walsh, Dominic M.
Publicado no Nat Commun (2018)

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

Por Nicoll, Andrew J., Panico, Silvia, Freir, Darragh B., Wright, Daniel, Terry, Cassandra, Risse, Emmanuel, Herron, Caroline E., O’Malley, Tiernan, Wadsworth, Jonathan D. F., Farrow, Mark A., Walsh, Dominic M., Saibil, Helen R., Collinge, John
Publicado em 2013

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier

Por Keaney, James, Walsh, Dominic M., O’Malley, Tiernan, Hudson, Natalie, Crosbie, Darragh E., Loftus, Teresa, Sheehan, Florike, McDaid, Jacqueline, Humphries, Marian M., Callanan, John J., Brett, Francesca M., Farrell, Michael A., Humphries, Peter, Campbell, Matthew
Publicado no Sci Adv (2015)