Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer’s Disease Disrupt Synaptic Plasticity

The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes of human iPSC-derived neuronal models of Alzheimer’s disease. When introduced i...

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Detalhes bibliográficos
Publicado no:Cell Rep
Principais autores: Hu, Neng-Wei, Corbett, Grant T., Moore, Steven, Klyubin, Igor, O’Malley, Tiernan T., Walsh, Dominic M., Livesey, Frederick J., Rowan, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972225/
https://ncbi.nlm.nih.gov/pubmed/29768194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.040
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