Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo

Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's disease (AD). For some time NFTs were considered the primary cause of synaptic dysfunction and neuronal death, how...

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Publicado en:J Neurosci
Autores principales: Ondrejcak, Tomas, Klyubin, Igor, Corbett, Grant T., Fraser, Graham, Hong, Wei, Mably, Alexandra J., Gardener, Matthew, Hammersley, Jayne, Perkinton, Michael S., Billinton, Andrew, Walsh, Dominic M., Rowan, Michael J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2018
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290298/
https://ncbi.nlm.nih.gov/pubmed/30355631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1700-18.2018
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