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Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus

Dysregulation of glutamate homeostasis in the interstitial fluid of the brain is strongly implicated in causing synaptic dysfunction in many neurological and psychiatric illnesses. In the case of Alzheimer's disease (AD), amyloid β (Aβ)-mediated disruption of synaptic plasticity and memory can...

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Veröffentlicht in:Cereb Cortex
Hauptverfasser: Zhang, Dainan, Mably, Alexandra J, Walsh, Dominic M, Rowan, Michael J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967354/
https://ncbi.nlm.nih.gov/pubmed/27390019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhw193
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