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The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer

Extracts of Alzheimer's disease (AD) brain that contain what appear to be SDS-stable amyloid β-protein (Aβ) dimers potently block LTP and impair memory consolidation. Brain-derived dimers can be physically separated from Aβ monomer, consist primarily of Aβ42 and resist denaturation by powerful...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: O'Malley, Tiernan T., Witbold, William M., Linse, Sara, Walsh, Dominic M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461814/
https://ncbi.nlm.nih.gov/pubmed/27750419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00453
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