The aqueous phase of Alzheimer’s disease brain contains assemblies built from ~4 and ~7 kDa Aβ species

Much of our knowledge about Aβ aggregation and toxicity has been acquired using synthetic peptides and mouse models, whereas less attention has been paid to soluble proteins present in human brain. Here we report that aqueous extracts of AD brain can contain at least four different Aβ assembly forms...

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Библиографические подробности
Опубликовано в: :Alzheimers Dement
Главные авторы: Mc Donald, Jessica M., O’Malley, Tiernan T., Liu, Wen, Mably, Alexandra J., Brinkmalm, Gunnar, Portelius, Erik, Wittbold, William M., Frosch, Matthew P., Walsh, Dominic M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592782/
https://ncbi.nlm.nih.gov/pubmed/25846299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.01.005
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