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Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain

Significant data suggest that soluble Aβ oligomers play an important role in Alzheimer’s disease (AD), but there is great confusion over what exactly constitutes an Aβ oligomer and which oligomers are toxic. Most studies have utilized synthetic Aβ peptides, but the relevance of these test tube exper...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Hong, Wei, Wang, Zemin, Liu, Wen, O’Malley, Tiernan T., Jin, Ming, Willem, Michael, Haass, Christian, Frosch, Matthew P., Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647843/
https://ncbi.nlm.nih.gov/pubmed/29687257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1846-7
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