Antiviral lectins: Selective inhibitors of viral entry

Por Mitchell, Carter A., Ramessar, Koreen, O'Keefe, Barry R.
Publicado no Antiviral Res (2017)

Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL)

Por Jakób, Michał, Lubkowski, Jacek, O’Keefe, Barry R., Wlodawer, Alexander
Publicado no Acta Crystallogr F Struct Biol Commun (2015)

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine

Por Ziółkowska, Natasza E., Shenoy, Shilpa R., O'Keefe, Barry R., Wlodawer, Alexander
Publicado em 2007

(−)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

Por Suzuki, Yuki, Saito, Yohei, Goto, Masuo, Newman, David J., O’Keefe, Barry R., Lee, Kuo-Hsiung, Nakagawa-Goto, Kyoko
Publicado no J Nat Prod (2017)

Topology of the disulfide bonds in the antiviral lectin scytovirin

Por Moulaei, Tinoush, Stuchlik, Olga, Reed, Matthew, Yuan, Weirong, Pohl, Jan, Lu, Wuyuan, Haugh-Krumpe, Lauren, O'Keefe, Barry R, Wlodawer, Alexander
Publicado em 2010

The lectins Griffithsin, Cyanovirin-N and Scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells

Por Alexandre, Kabamba B., Gray, Elin S., Mufhandu, Hazel, McMahon, James B., Chakauya, Ereck, O’Keefe, Barry R., Chikwamba, Rachel, Morris, Lynn
Publicado em 2011

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

Por Moulaei, Tinoush, Shenoy, Shilpa R., Giomarelli, Barbara, Thomas, Cheryl, McMahon, James B., Dauter, Zbigniew, O'Keefe, Barry R., Wlodawer, Alexander
Publicado em 2010

Differential Inhibitory Effects of Cyanovirin-N, Griffithsin, and Scytovirin on Entry Mediated by Envelopes of Gammaretroviruses and Deltaretroviruses

Por Jensen, Stig M. R., Ruscetti, Francis W., Rein, Alan, Bertolette, Daniel C., Saucedo, Carrie J., O'Keefe, Barry R., Jones, Kathryn S.
Publicado em 2014

Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

Por Witvrouw, Myriam, Fikkert, Valery, Hantson, Anke, Pannecouque, Christophe, O'Keefe, Barry R., McMahon, James, Stamatatos, Leonidas, de Clercq, Erik, Bolmstedt, Anders
Publicado em 2005

Treatment of Influenza A (H1N1) Virus Infections in Mice and Ferrets with Cyanovirin-N

Por Smee, Donald F., Bailey, Kevin W., Wong, Min-Hui, O’Keefe, Barry R., Gustafson, Kirk R., Mishin, Vasiliy P., Gubareva, Larisa V.
Publicado em 2008

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

Por Sztuba-Solinska, Joanna, Shenoy, Shilpa R., Gareiss, Peter, Krumpe, Lauren R. H., Le Grice, Stuart F. J., O’Keefe, Barry R., Schneekloth, John S.
Publicado no J Am Chem Soc (2014)

Rice endosperm is cost‐effective for the production of recombinant griffithsin with potent activity against HIV

Por Vamvaka, Evangelia, Arcalis, Elsa, Ramessar, Koreen, Evans, Abbey, O'Keefe, Barry R., Shattock, Robin J., Medina, Vicente, Stöger, Eva, Christou, Paul, Capell, Teresa
Publicado no Plant Biotechnol J (2016)

Corymbulosins D–H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Por Suzuki, Airi, Saito, Yohei, Fukuyoshi, Shuichi, Goto, Masuo, Miyake, Katsunori, Newman, David J., O’Keefe, Barry R., Lee, Kuo-Hsiung, Nakagawa-Goto, Kyoko
Publicado no J Nat Prod (2017)

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

Por Alexandre, Kabamba Bankoledi, Gray, Elin S., Pantophlet, Ralph, Moore, Penny L., McMahon, James B., Chakauya, Ereck, O'Keefe, Barry R., Chikwamba, Rachel, Morris, Lynn
Publicado em 2011

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin

Por O'Keefe, Barry R., Smee, Donald F., Turpin, Jim A., Saucedo, Carrie J., Gustafson, Kirk R., Mori, Toshiyuki, Blakeslee, Dennis, Buckheit, Robert, Boyd, Michael R.
Publicado em 2003

Atomic-resolution crystal structure of the antiviral lectin scytovirin

Por Moulaei, Tinoush, Botos, Istvan, Ziółkowska, Natasza E., Bokesch, Heidi R., Krumpe, Lauren R., McKee, Tawnya C., O'Keefe, Barry R., Dauter, Zbigniew, Wlodawer, Alexander
Publicado em 2007

Discovery of New Pyridoacridine Alkaloids from Lissoclinum cf. badium that Inhibit the Ubiquitin Ligase Activity of Hdm2 and Stabilize p53

Por Clement, Jason A., Kitagaki, Jirouta, Yang, Yili, Saucedo, Carrie J., O’Keefe, Barry R., Weissman, Allan M., McKee, Tawnya C., McMahon, James B.
Publicado em 2008

Acetophenone Monomers from Acronychia trifoliolata

Por Miyake, Katsunori, Suzuki, Airi, Morita, Chihiro, Goto, Masuo, Newman, David J., O’Keefe, Barry R., Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Nakagawa-Goto, Kyoko
Publicado no J Nat Prod (2016)

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

Por Kouokam, Joseph Calvin, Huskens, Dana, Schols, Dominique, Johannemann, Andrew, Riedell, Shonna K., Walter, Wendye, Walker, Janice M., Matoba, Nobuyuki, O'Keefe, Barry R., Palmer, Kenneth E.
Publicado em 2011

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

Por Alexandre, Kabamba B., Moore, Penny L., Nonyane, Molati, Gray, Elin S., Ranchobe, Nthabeleng, Chakauya, Ereck, McMahon, James B., O’Keefe, Barry R., Chikwamba, Rachel, Morris, Lynn
Publicado em 2013