Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

The glycans on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study, we investigated the interaction of the lectin griffithsin (GRFT) with HIV-1 gp120 and its...

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Hlavní autoři: Alexandre, Kabamba Bankoledi, Gray, Elin S., Pantophlet, Ralph, Moore, Penny L., McMahon, James B., Chakauya, Ereck, O'Keefe, Barry R., Chikwamba, Rachel, Morris, Lynn
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165825/
https://ncbi.nlm.nih.gov/pubmed/21697467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02675-10
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