The lectins Griffithsin, Cyanovirin-N and Scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells

It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) inhibit HIV-1 infection by binding to mannose-rich glycans o...

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Autors principals: Alexandre, Kabamba B., Gray, Elin S., Mufhandu, Hazel, McMahon, James B., Chakauya, Ereck, O’Keefe, Barry R., Chikwamba, Rachel, Morris, Lynn
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274779/
https://ncbi.nlm.nih.gov/pubmed/22209231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.12.001
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