Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

Griffithsin (GRFT), Cyanovirin-N (CV-N) and Scytovirin (SVN) are lectins that inhibit HIV-1 infection by binding to multiple mannose-rich glycans on the HIV-1 envelope glycoproteins (Env). Here we show that these lectins neutralize subtype C primary virus isolates in addition to Env-pseudotyped viru...

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Main Authors: Alexandre, Kabamba B., Gray, Elin S., Lambson, Bronwen E., Moore, Penny L., Choge, Isaac A., Mlisana, Koleka, Abdool Karim, Salim S., McMahon, James, O’Keefe, Barry, Chikwamba, Rachel, Morris, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401642/
https://ncbi.nlm.nih.gov/pubmed/20392471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.03.021
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