Discovery of New Pyridoacridine Alkaloids from Lissoclinum cf. badium that Inhibit the Ubiquitin Ligase Activity of Hdm2 and Stabilize p53

Compounds that stabilize p53 could suppress tumors providing a additional tool to fight cancer. Mdm2, and the human ortholog, Hdm2 serve as ubiquitin E3 ligases and target p53 for ubiquitylation and degradation. Inhibition of Hdm2 stabilizes p53, inhibits cell proliferation and induces apoptosis. Us...

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Detalhes bibliográficos
Main Authors: Clement, Jason A., Kitagaki, Jirouta, Yang, Yili, Saucedo, Carrie J., O’Keefe, Barry R., Weissman, Allan M., McKee, Tawnya C., McMahon, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718708/
https://ncbi.nlm.nih.gov/pubmed/18977148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.024
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