Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

Mutations were introduced to the domain-swapped homodimer of the antiviral lectin griffithsin (GRFT). Whereas several single and double mutants remained dimeric, insertion of either two or four amino acids at the dimerization interface resulted in a monomeric form of the protein (mGRFT). Monomeric c...

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Main Authors: Moulaei, Tinoush, Shenoy, Shilpa R., Giomarelli, Barbara, Thomas, Cheryl, McMahon, James B., Dauter, Zbigniew, O'Keefe, Barry R., Wlodawer, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399781/
https://ncbi.nlm.nih.gov/pubmed/20826337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.05.016
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