Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have potent in vitro activity against viruses that display dense clusters of oligomannose N-linked glycans (NLG) on their surface envelope glycoproteins. However, since oligomannose NLG are also found on some host p...

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Main Authors: Kouokam, Joseph Calvin, Huskens, Dana, Schols, Dominique, Johannemann, Andrew, Riedell, Shonna K., Walter, Wendye, Walker, Janice M., Matoba, Nobuyuki, O'Keefe, Barry R., Palmer, Kenneth E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149051/
https://ncbi.nlm.nih.gov/pubmed/21829638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022635
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