Treatment of Influenza A (H1N1) Virus Infections in Mice and Ferrets with Cyanovirin-N

Cyanovirin-N (CV-N), a protein derived from Nostoc ellipsosporum, neutralizes influenza virus infectivity by binding to specific high-mannose oligosaccharides (oligomannose-8 and -9) at glycosylation sites on the viral hemagglutinin HA1 subunit. Mouse-adapted viruses lose sensitivity to CV-N due to...

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Main Authors: Smee, Donald F., Bailey, Kevin W., Wong, Min-Hui, O’Keefe, Barry R., Gustafson, Kirk R., Mishin, Vasiliy P., Gubareva, Larisa V.
格式: Artigo
語言:Inglês
出版: 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740641/
https://ncbi.nlm.nih.gov/pubmed/18601954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.06.003
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