BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

Por Kirsch, Thomas, Nickel, Joachim, Sebald, Walter
Publicado em 2000

Crystallization and preliminary X-ray diffraction analysis of human growth and differentiation factor 5 (GDF-5)

Por Mueller, Thomas D., Gottermeier, Maike, Sebald, Walter, Nickel, Joachim
Publicado em 2004

Purification, crystallization and preliminary data analysis of ligand–receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB)

Por Kotzsch, Alexander, Nickel, Joachim, Sebald, Walter, Mueller, Thomas D.
Publicado em 2009

Purification, crystallization and preliminary data analysis of the ligand–receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (B...

Por Nickel, Joachim, Kotzsch, Alexander, Sebald, Walter, Mueller, Thomas D.
Publicado em 2011

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5–type I receptor specificity

Por Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Sebald, Walter, Müller, Thomas D
Publicado em 2009

Receptor oligomerization and beyond: a case study in bone morphogenetic proteins

Por Heinecke, Kai, Seher, Axel, Schmitz, Werner, Mueller, Thomas D, Sebald, Walter, Nickel, Joachim
Publicado em 2009

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor

Por Kraich, Michael, Klein, Markus, Patiño, Edwin, Harrer, Henning, Nickel, Joachim, Sebald, Walter, Mueller, Thomas D
Publicado em 2006

Biological activity of a genetically modified BMP-2 variant with inhibitory activity

Por Klammert, Uwe, Nickel, Joachim, Würzler, Kristian, Klingelhöffer, Christoph, Sebald, Walter, Kübler, Alexander C, Reuther, Tobias
Publicado em 2009

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor

Por Weber, Dionys, Kotzsch, Alexander, Nickel, Joachim, Harth, Stefan, Seher, Axel, Mueller, Uwe, Sebald, Walter, Mueller, Thomas D
Publicado em 2007

Functional Antibodies Targeting IsaA of Staphylococcus aureus Augment Host Immune Response and Open New Perspectives for Antibacterial Therapy

Por Lorenz, Udo, Lorenz, Birgit, Schmitter, Tim, Streker, Karin, Erck, Christian, Wehland, Jürgen, Nickel, Joachim, Zimmermann, Bastian, Ohlsen, Knut
Publicado em 2011

Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro

Por Seher, Axel, Nickel, Joachim, Mueller, Thomas D., Kneitz, Susanne, Gebhardt, Susanne, ter Vehn, Tobias Meyer, Schlunck, Guenther, Sebald, Walter
Publicado em 2011

Mode-of-Action Studies of the Novel Bisquaternary Bisnaphthalimide MT02 against Staphylococcus aureus

Por Menzel, Thomas M., Tischer, Maximilian, François, Patrice, Nickel, Joachim, Schrenzel, Jacques, Bruhn, Heike, Albrecht, Annette, Lehmann, Leane, Holzgrabe, Ulrike, Ohlsen, Knut
Publicado em 2011

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)

Por Diestel, Uschi, Resch, Marcus, Meinhardt, Kathrin, Weiler, Sigrid, Hellmann, Tina V., Mueller, Thomas D., Nickel, Joachim, Eichler, Jutta, Muller, Yves A.
Publicado em 2013

Utilizing BMP-2 muteins for treatment of multiple myeloma

Por Seher, Axel, Lagler, Charlotte, Stühmer, Thorsten, Müller-Richter, Urs Dietmar Achim, Kübler, Alexander Christian, Sebald, Walter, Müller, Thomas Dieter, Nickel, Joachim
Publicado no PLoS One (2017)

GDF-5 can act as a context-dependent BMP-2 antagonist

Por Klammert, Uwe, Mueller, Thomas D., Hellmann, Tina V., Wuerzler, Kristian K., Kotzsch, Alexander, Schliermann, Anna, Schmitz, Werner, Kuebler, Alexander C., Sebald, Walter, Nickel, Joachim
Publicado no BMC Biol (2015)

The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent

Por Lagler, Charlotte, El-Mesery, Mohamed, Kübler, Alexander Christian, Müller-Richter, Urs Dietmar Achim, Stühmer, Thorsten, Nickel, Joachim, Müller, Thomas Dieter, Wajant, Harald, Seher, Axel
Publicado no PLoS One (2017)

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

Por Seemann, Petra, Schwappacher, Raphaela, Kjaer, Klaus W., Krakow, Deborah, Lehmann, Katarina, Dawson, Katherine, Stricker, Sigmar, Pohl, Jens, Plöger, Frank, Staub, Eike, Nickel, Joachim, Sebald, Walter, Knaus, Petra, Mundlos, Stefan
Publicado em 2005

A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2

Por Degenkolbe, Elisa, König, Jana, Zimmer, Julia, Walther, Maria, Reißner, Carsten, Nickel, Joachim, Plöger, Frank, Raspopovic, Jelena, Sharpe, James, Dathe, Katarina, Hecht, Jacqueline T., Mundlos, Stefan, Doelken, Sandra C., Seemann, Petra
Publicado em 2013

Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN

Por Seemann, Petra, Brehm, Anja, König, Jana, Reissner, Carsten, Stricker, Sigmar, Kuss, Pia, Haupt, Julia, Renninger, Stephanie, Nickel, Joachim, Sebald, Walter, Groppe, Jay C., Plöger, Frank, Pohl, Jens, Schmidt-von Kegler, Mareen, Walther, Maria, Gassner, Ingmar, Rusu, Cristina, Janecke, Andreas R., Dathe, Katarina, Mundlos, Stefan
Publicado em 2009