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A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor
BACKGROUND: Bone morphogenetic proteins (BMPs) are key regulators in the embryonic development and postnatal tissue homeostasis in all animals. Loss of function or dysregulation of BMPs results in severe diseases or even lethality. Like transforming growth factors β (TGF-βs), activins, growth and di...
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| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BioMed Central
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1802081/ https://ncbi.nlm.nih.gov/pubmed/17295905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-6 |
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