A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor

BACKGROUND: Bone morphogenetic proteins (BMPs) are key regulators in the embryonic development and postnatal tissue homeostasis in all animals. Loss of function or dysregulation of BMPs results in severe diseases or even lethality. Like transforming growth factors β (TGF-βs), activins, growth and di...

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Hlavní autoři: Weber, Dionys, Kotzsch, Alexander, Nickel, Joachim, Harth, Stefan, Seher, Axel, Mueller, Uwe, Sebald, Walter, Mueller, Thomas D
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802081/
https://ncbi.nlm.nih.gov/pubmed/17295905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-6
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