Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5–type I receptor specificity

Dysregulation of growth and differentiation factor 5 (GDF-5) signalling, a member of the TGF-β superfamily, is strongly linked to skeletal malformation. GDF-5-mediated signal transduction involves both BMP type I receptors, BMPR-IA and BMPR-IB. However, mutations in either GDF-5 or BMPR-IB lead to s...

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Detalhes bibliográficos
Main Authors: Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Sebald, Walter, Müller, Thomas D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670865/
https://ncbi.nlm.nih.gov/pubmed/19229295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.37
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