Raltegravir: molecular basis of its mechanism of action

door Mouscadet, Jean-François, Tchertanov, Luba
Gepubliceerd in 2009

Chemistry and Structure-Activity Relationship of the Styrylquinoline-Type HIV Integrase Inhibitors

door Mouscadet, Jean-François, Desmaële, Didier
Gepubliceerd in Molecules (2010)

Integrase and integration: biochemical activities of HIV-1 integrase

door Delelis, Olivier, Carayon, Kevin, Saïb, Ali, Deprez, Eric, Mouscadet, Jean-François
Gepubliceerd in 2008

Structure–Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors

door Agapkina, Julia, Zatsepin, Timofei, Knyazhanskaya, Ekaterina, Mouscadet, Jean-Francois, Gottikh, Marina
Gepubliceerd in 2011

Disulfide-Linked Integrase Oligomers Involving C280 Residues Are Formed In Vitro and In Vivo but Are Not Essential for Human Immunodeficiency Virus Replication

door Bischerour, Julien, Leh, Hervé, Deprez, Eric, Brochon, Jean-Claude, Mouscadet, Jean-François
Gepubliceerd in 2003

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles

door Mouscadet Jean-François, Mbemba Gladys, Leh Herve, Petit Caroline, Delelis Olivier, Sonigo Pierre
Gepubliceerd in 2005-05-01

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles

door Delelis, Olivier, Petit, Caroline, Leh, Herve, Mbemba, Gladys, Mouscadet, Jean-François, Sonigo, Pierre
Gepubliceerd in 2005

A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain

door Carayon, Kevin, Leh, Hervé, Henry, Etienne, Simon, Françoise, Mouscadet, Jean-François, Deprez, Eric
Gepubliceerd in 2010

The (52–96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA

door Bischerour, Julien, Tauc, Patrick, Leh, Hervé, de Rocquigny, Hugues, Roques, Bernard, Mouscadet, Jean-François
Gepubliceerd in 2003

DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study

door Deprez, Eric, Tauc, Patrick, Leh, Hervé, Mouscadet, Jean-François, Auclair, Christian, Hawkins, Mary E., Brochon, Jean-Claude
Gepubliceerd in 2001

Efficient and Specific Internal Cleavage of a Retroviral Palindromic DNA Sequence by Tetrameric HIV-1 Integrase

door Delelis, Olivier, Parissi, Vincent, Leh, Hervé, Mbemba, Gladys, Petit, Caroline, Sonigo, Pierre, Deprez, Eric, Mouscadet, Jean-François
Gepubliceerd in 2007

G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does not

door Ni, Xiao-Ju, Delelis, Olivier, Charpentier, Charlotte, Storto, Alexandre, Collin, Gilles, Damond, Florence, Descamps, Diane, Mouscadet, Jean-François
Gepubliceerd in 2011

Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase, RNase H, and Integrase Activities by Hydroxytropolones

door Didierjean, Joël, Isel, Catherine, Querré, Flore, Mouscadet, Jean-François, Aubertin, Anne-Marie, Valnot, Jean-Yves, Piettre, Serge R., Marquet, Roland
Gepubliceerd in 2005

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

door Delelis, Olivier, Malet, Isabelle, Na, Li, Tchertanov, Luba, Calvez, Vincent, Marcelin, Anne-Genevieve, Subra, Frederic, Deprez, Eric, Mouscadet, Jean-François
Gepubliceerd in 2009

G140S mutation rescues HIV-1 IN integration defect due to Q148H in vitro and in vivo

door Delelis, Olivier, Malet, Isabelle, Tchertanov, Luba, Na, Li, Calvez, Vincent, Marcellin, Anne-Geneviève, Subra, Frédéric, Deprez, Eric, Mouscadet, Jean-Francois
Gepubliceerd in 2009

In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors

door Ni, Xiaoju, Abdel-Azeim, Safwat, Laine, Elodie, Arora, Rohit, Osemwota, Osamuede, Marcelin, Anne-Geneviève, Calvez, Vincent, Mouscadet, Jean-François, Tchertanov, Luba
Gepubliceerd in 2012

Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents

door Bonnenfant, Sabine, Thomas, Claire Marie, Vita, Claudio, Subra, Frédéric, Deprez, Eric, Zouhiri, Fatima, Desmaële, Didier, d'Angelo, Jean, Mouscadet, Jean François, Leh, Hervé
Gepubliceerd in 2004

Structural basis for HIV-1 DNA integration in the human genome

door Michel, Fabrice, Eiler, Sylvia, Granger, Florence, Mouscadet, Jean-François, Gottikh, Marina, Nazabal, Alexis, Emiliani, Stéphane, Benarous, Richard, Moras, Dino, Schultz, Patrick, Ruff, Marc
Gepubliceerd in 2009

The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages

door David, Annie, Sáez-Cirión, Asier, Versmisse, Pierre, Malbec, Odile, Iannascoli, Bruno, Herschke, Florence, Lucas, Marianne, Barré-Sinoussi, Françoise, Mouscadet, Jean-François, Daëron, Marc, Pancino, Gianfranco
Gepubliceerd in 2006

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA

door Lyonnais, Sébastien, Gorelick, Robert J., Heniche-Boukhalfa, Fatima, Bouaziz, Serge, Parissi, Vincent, Mouscadet, Jean-François, Restle, Tobias, Gatell, Jose Maria, Le Cam, Eric, Mirambeau, Gilles
Gepubliceerd in 2012