The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

Raltegravir (MK-0518) is the first integrase (IN) inhibitor to be approved by the US FDA and is currently used in clinical treatment of viruses resistant to other antiretroviral compounds. Virological failure of Raltegravir treatment is associated with mutations in the IN gene following two main dis...

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Main Authors: Delelis, Olivier, Malet, Isabelle, Na, Li, Tchertanov, Luba, Calvez, Vincent, Marcelin, Anne-Genevieve, Subra, Frederic, Deprez, Eric, Mouscadet, Jean-François
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651800/
https://ncbi.nlm.nih.gov/pubmed/19129221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1050
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