Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Raltegravir (MK-0518) is a potent inhibitor of human immunodeficiency virus (HIV) integrase and is clinically effective against viruses resistant to other classes of antiretroviral agents. However, it can select mutations in the HIV integrase gene. Nine heavily pretreated patients who received salva...

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Bibliografiske detaljer
Main Authors: Malet, Isabelle, Delelis, Olivier, Valantin, Marc-Antoine, Montes, Brigitte, Soulie, Cathia, Wirden, Marc, Tchertanov, Luba, Peytavin, Gilles, Reynes, Jacques, Mouscadet, Jean-François, Katlama, Christine, Calvez, Vincent, Marcelin, Anne-Geneviève
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292515/
https://ncbi.nlm.nih.gov/pubmed/18227187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01228-07
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