Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Raltegravir (MK-0518) is a potent inhibitor of human immunodeficiency virus (HIV) integrase and is clinically effective against viruses resistant to other classes of antiretroviral agents. However, it can select mutations in the HIV integrase gene. Nine heavily pretreated patients who received salva...

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Detaylı Bibliyografya
Asıl Yazarlar: Malet, Isabelle, Delelis, Olivier, Valantin, Marc-Antoine, Montes, Brigitte, Soulie, Cathia, Wirden, Marc, Tchertanov, Luba, Peytavin, Gilles, Reynes, Jacques, Mouscadet, Jean-François, Katlama, Christine, Calvez, Vincent, Marcelin, Anne-Geneviève
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2008
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292515/
https://ncbi.nlm.nih.gov/pubmed/18227187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01228-07
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