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Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Raltegravir (MK-0518) is a potent inhibitor of human immunodeficiency virus (HIV) integrase and is clinically effective against viruses resistant to other classes of antiretroviral agents. However, it can select mutations in the HIV integrase gene. Nine heavily pretreated patients who received salva...

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מידע ביבליוגרפי
Main Authors: Malet, Isabelle, Delelis, Olivier, Valantin, Marc-Antoine, Montes, Brigitte, Soulie, Cathia, Wirden, Marc, Tchertanov, Luba, Peytavin, Gilles, Reynes, Jacques, Mouscadet, Jean-François, Katlama, Christine, Calvez, Vincent, Marcelin, Anne-Geneviève
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292515/
https://ncbi.nlm.nih.gov/pubmed/18227187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01228-07
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