Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Raltegravir (MK-0518) is a potent inhibitor of human immunodeficiency virus (HIV) integrase and is clinically effective against viruses resistant to other classes of antiretroviral agents. However, it can select mutations in the HIV integrase gene. Nine heavily pretreated patients who received salva...

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Detalhes bibliográficos
Main Authors: Malet, Isabelle, Delelis, Olivier, Valantin, Marc-Antoine, Montes, Brigitte, Soulie, Cathia, Wirden, Marc, Tchertanov, Luba, Peytavin, Gilles, Reynes, Jacques, Mouscadet, Jean-François, Katlama, Christine, Calvez, Vincent, Marcelin, Anne-Geneviève
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292515/
https://ncbi.nlm.nih.gov/pubmed/18227187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01228-07
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