Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

Raltegravir (MK-0518) is a potent inhibitor of human immunodeficiency virus (HIV) integrase and is clinically effective against viruses resistant to other classes of antiretroviral agents. However, it can select mutations in the HIV integrase gene. Nine heavily pretreated patients who received salva...

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Hlavní autoři: Malet, Isabelle, Delelis, Olivier, Valantin, Marc-Antoine, Montes, Brigitte, Soulie, Cathia, Wirden, Marc, Tchertanov, Luba, Peytavin, Gilles, Reynes, Jacques, Mouscadet, Jean-François, Katlama, Christine, Calvez, Vincent, Marcelin, Anne-Geneviève
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292515/
https://ncbi.nlm.nih.gov/pubmed/18227187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01228-07
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